Ketopantoate hydroxymethyltransferase. II. Physical, catalytic, and regulatory properties.

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Experimental and Metabolic Modeling Evidence for a Folate-Cleaving Side-Activity of Ketopantoate Hydroxymethyltransferase (PanB)

Tetrahydrofolate (THF) and its one-carbon derivatives, collectively termed folates, are essential cofactors, but are inherently unstable. While it is clear that chemical oxidation can cleave folates or damage their pterin precursors, very little is known about enzymatic damage to these molecules or about whether the folate biosynthesis pathway responds adaptively to damage to its end-products. ...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1976

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(17)33413-0